Episode 3: Change Changing Places
Original Publish Date
February 17, 2021
Episode Description
Does CMT change types from one generation to the next? Can CMT change types? Can somebody inherit a different type of CMT than what their mom or dad has? The answers are easy, but getting to the why and how behind the answer requires a little bit of digging.
Show Notes
In this episode, we tackle the questions about CMT changing types through inheritance and explain the how and why behind some families having more than one type of CMT.
Sources
Johns Hopkins Online Mendelian Inheritance in Man (OMIM) CMT Phenotype Series
https://www.omim.org/phenotypicSeries/PS162400
What is a Chromosome?
https://www.genome.gov/genetics-glossary/Chromosome
What is an Autosome?
https://www.genome.gov/genetics-glossary/Autosome
Inheritance Patterns and Mutation Types:
https://www.ncbi.nlm.nih.gov/books/NBK115561/
A Gene’s Home Address:
https://medlineplus.gov/genetics/understanding/howgeneswork/genelocation/
The Human Genome Project
https://www.genome.gov/
The Cryptid Sloth Show Ep 1: It’s All In The Genes:
https://thecryptidslothshow.buzzsprout.com/1550245/7360330-ep-1-it-s-all-in-the-genes
The Human Genome Project:
https://www.genome.gov/human-genome-project
CMT Type Categories and Associated Subtypes
CMT1:
https://www.thecryptidsloth.com/cmt1
CMT2:
https://www.thecryptidsloth.com/cmt2
CMT4:
https://www.thecryptidsloth.com/cmt4
X-Linked CMT:
https://www.thecryptidsloth.com/cmtx
Dominant Intermediate CMT:
https://www.thecryptidsloth.com/cmt-di
Recessive Intermediate CMT:
https://www.thecryptidsloth.com/cmt-ri
HNPP:
https://www.thecryptidsloth.com/cmt1/hnpp
https://www.cmtausa.org/understanding-cmt/types-of-cmt/hereditary-neuropathy-with-liability-to-pressure-palsies-hnpp/
Referenced CMT Types
CMT1A: https://www.thecryptidsloth.com/cmt1/cmt1a
CMT4H: https://www.thecryptidsloth.com/cmt4/cmt4h
Additional CMT Resources
Find Your Nearest Charcot-Marie-Tooth Association Centers of Excellence CMT Clinic:
https://www.cmtausa.org/living-with-cmt/find-help/cmta-centers-of-excellence/
The CMTA’s Ask the Expert Desk:
https://www.cmtausa.org/living-with-cmt/find-help/ask-the-expert/
The Inherited Neuropathies Consortium:
https://www.rarediseasesnetwork.org/cms/inc/
The Hereditary Neuropathy Foundation
https://www.hnf-cure.org/